A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older (BEETHOVEN)

Study Description

A study of how safe and effective a C. Diff vaccine can be in decreasing infections.

Study Details

Registry ID:

NCT07282665

Conditions:

Clostridioides Difficile Associated Disease

Phase:

Phase 3

Target Enrollment:

32,000 participants

Start Date:

December 10, 2025

Healthy Volunteers:

No

Study Locations (177 sites)

• Wake Forest Baptist Health
  Winston-Salem, North CarolinaUnited States, United States
• Japan Community Healthcare Organization Kyushu Hospital
  Kitakyushu-shi, FukuokaJapan, Japan
• Knowle House Surgery
  Plymouth, DevonUnited Kingdom, United Kingdom
• Brunel Medical Practice (St Marychurch)
  Torquay, DevonUnited Kingdom, United Kingdom
• Newquay Health Centre
  Newquay, CornwallUnited Kingdom, United Kingdom
• Royal Devon & Exeter Hospital
  Exeter, DevonUnited Kingdom, United Kingdom
• Southampton General Hospital
  Southampton, HampshireUnited Kingdom, United Kingdom
• Lakeside Surgery
  Corby, NorthamptonshireUnited Kingdom, United Kingdom
• Synexus Midlands Clinical Research Centre
  BirminghamUnited Kingdom, United Kingdom
• Synexus Midlands Clinical Research Centre
  Birmingham, WEST MidlandsUnited Kingdom, United Kingdom
• Cheadle Community Hospital
  Cheadle, StaffordshireUnited Kingdom, United Kingdom
• North Wales Clinical Research Facility
  Wrexham, Wrexham [wrecsam Gb-wrc]United Kingdom, United Kingdom
• Panthera Biopartners - Sheffield
  SheffieldUnited Kingdom, United Kingdom
• Synexus Manchester Clinical Research Centre
  ManchesterUnited Kingdom, United Kingdom
• Manchester Royal Infirmary
  ManchesterUnited Kingdom, United Kingdom
• Panthera Biopartners - Manchester
  Rochdale, ManchesterUnited Kingdom, United Kingdom
• Panthera Biopartners - Preston
  Preston, EnglandUnited Kingdom, United Kingdom
• Layton Medical Centre
  Blackpool, LancashireUnited Kingdom, United Kingdom
• Panthera Clinic - York
  York, North YorkshireUnited Kingdom, United Kingdom
• Ormeau Clinical Trials
  Belfast, Northern IrelandUnited Kingdom, United Kingdom
• Synexus Scotland Clinical Research Centre
  Glasgow, Glasgow CITYUnited Kingdom, United Kingdom
• Panthera Biopartners - Glasgow
  Glasgow, ScotlandUnited Kingdom, United Kingdom
• Panthera Biopartners - Glasgow
  GlasgowUnited Kingdom, United Kingdom
• Equipo Ciencia
  Buenos Aires, Buenos Aires F.D.Argentina, Argentina
• Sanatorio Sagrado Corazón
  Buenos AiresArgentina, Argentina
• Fundación Huésped
  Buenos Aires, Buenos Aires F.D.Argentina, Argentina
• Centro Medico Barrio Parque
  Buenos AiresArgentina, Argentina
• Clinica Del Niño Y La Madre
  Mar del Plata, Buenos AiresArgentina, Argentina
• Investigaciones Clínicas Salta (ICSAL)
  SaltaArgentina, Argentina
• Clinica Privada del Sol S.A
  Córdoba, Córdoba ProvinceArgentina, Argentina
• CDC Centro Médico
  Luján de Cuyo, Mendoza ProvinceArgentina, Argentina
• NYU Langone Health
  Mineola, New YorkUnited States, United States
• Care Research Inc
  Miami, FloridaUnited States, United States
• Entrust Clinical Research
  Miami, FloridaUnited States, United States
• North Shore University Hospital
  Manhasset, New YorkUnited States, United States
• Northwell Health Infectious Disease
  Manhasset, New YorkUnited States, United States
• Hackensack Meridian Jersey Shore University Medical Center
  Neptune City, New JerseyUnited States, United States
• HOPE Tower at Jersey Shore University Medical Center
  Neptune City, New JerseyUnited States, United States
• Proactive Clinical Research,LLC
  Fort Lauderdale, FloridaUnited States, United States
• Innovation Medical Research Center
  Palmetto Bay, FloridaUnited States, United States
• South Jersey Infectious Disease
  Somers Point, New JerseyUnited States, United States
• Indago Research & Health Center, Inc
  Hialeah, FloridaUnited States, United States
• South Florida Research Organization
  Medley, FloridaUnited States, United States
• Charisma Medical and Research Center
  Miami Lakes, FloridaUnited States, United States
• Palm Springs Community Health Center
  Miami Lakes, FloridaUnited States, United States
• NYU Langone Health
  Brooklyn, New YorkUnited States, United States
• Montefiore Medical Center
  The Bronx, New YorkUnited States, United States
• James J. Peters VA Medical Center
  The Bronx, New YorkUnited States, United States
• Mount Sinai Queens
  Long Island City, New YorkUnited States, United States
• Northern Westchester Hospital
  Mount Kisco, New YorkUnited States, United States
• NYU Langone Health
  New York, New YorkUnited States, United States
• Mount Sinai West
  New York, New YorkUnited States, United States
• Mount Sinai Morningside
  New York, New YorkUnited States, United States
• Icahn School of Medicine at Mount Sinai
  New York, New YorkUnited States, United States
• Columbia University Irving Medical Center
  New York, New YorkUnited States, United States
• Phelps Hospital Geriatric Medicine & Improvement Science
  Sleepy Hollow, New YorkUnited States, United States
• Hackensack Meridian Health Hackensack University Medical Center
  Hackensack, New JerseyUnited States, United States
• HMH David Jurist Research Building
  Hackensack, New JerseyUnited States, United States
• HMH Hackensack University Medical Center
  Hackensack, New JerseyUnited States, United States
• Rutgers Robert Wood Johnson Medical School
  New Brunswick, New JerseyUnited States, United States
• DM Clinical Research - Philadelphia
  Philadelphia, PennsylvaniaUnited States, United States
• Accellacare - Wilmington
  Wilmington, North CarolinaUnited States, United States
• Wilmington Health, PLLC
  Wilmington, North CarolinaUnited States, United States
• Walker Family Care
  Little River, South CarolinaUnited States, United States
• The University of Vermont Medical Center Inc.
  Burlington, VermontUnited States, United States
• UVM Larner College of Medicine MMG/VCT
  Burlington, VermontUnited States, United States
• Trial Management Associates, LLC
  Myrtle Beach, South CarolinaUnited States, United States
• Trial Management Associates
  Myrtle Beach, South CarolinaUnited States, United States
• Clinical Research Partners, LLC
  Richmond, VirginiaUnited States, United States
• Johns Hopkins Bloomberg School of Public Health
  Baltimore, MarylandUnited States, United States
• GW Vaccine Research Unit
  Washington D.C., District of ColumbiaUnited States, United States
• The GW Medical Faculty Associates
  Washington D.C., District of ColumbiaUnited States, United States
• Accellacare - Raleigh
  Raleigh, North CarolinaUnited States, United States
• Duke University Health System
  Raleigh, North CarolinaUnited States, United States
• Raleigh Medical Group P.A.
  Raleigh, North CarolinaUnited States, United States
• Accellacare - Cary
  Cary, North CarolinaUnited States, United States
• Duke Vaccine and Trials Unit
  Durham, North CarolinaUnited States, United States
• Capital Area Research, LLC
  Camp Hill, PennsylvaniaUnited States, United States
• Angels Clinical Research Institute
  Tampa, FloridaUnited States, United States
• Clinical Neuroscience Solutions, Inc. dba CNS Healthcare
  Jacksonville, FloridaUnited States, United States
• Velocity Clinical Research, Savannah
  Savannah, GeorgiaUnited States, United States
• Bay Pines VA Healthcare System
  Bay Pines, FloridaUnited States, United States
• Upstate Global Health Institute
  East Syracuse, New YorkUnited States, United States
• Medication Management
  Greensboro, North CarolinaUnited States, United States
• Atrium Health Wake Forest Baptist Infectious Disease-High Point
  High Point, North CarolinaUnited States, United States
• Wake Forest University Health Science
  High Point, North CarolinaUnited States, United States
• M3 Wake Research - Lake City
  Lake City, FloridaUnited States, United States
• Accellacare - Winston-Salem
  Winston-Salem, North CarolinaUnited States, United States
• Wake Forest Baptist Health
  Winston-Salem, North CarolinaUnited States, United States
• Accellacare - Salisbury
  Salisbury, North CarolinaUnited States, United States
• Rochester Clinical Research, LLC
  Rochester, New YorkUnited States, United States
• Accellacare - Hickory
  Hickory, North CarolinaUnited States, United States
• Velocity Clinical Research, Spartanburg
  Spartanburg, South CarolinaUnited States, United States
• The Hope Clinic of Emory University
  Decatur, GeorgiaUnited States, United States
• Emory Steiner Building Research Center
  Atlanta, GeorgiaUnited States, United States
• Emory University Woodruff Extension Building (WEB)
  Atlanta, GeorgiaUnited States, United States
• Centricity Research Columbus Georgia Multispecialty
  Columbus, GeorgiaUnited States, United States
• New Phase Research and Development
  Knoxville, TennesseeUnited States, United States
• VA Northeast Ohio Healthcare System Louis Stokes Cleveland VA Medical Center
  Cleveland, OhioUnited States, United States
• Lakeview Clinical Research
  Guntersville, AlabamaUnited States, United States
• CTI Clinical Research Center
  Cincinnati, OhioUnited States, United States
• Medical Affiliated Research Center
  Huntsville, AlabamaUnited States, United States
• Revive Research Institute, Inc.
  Southfield, MichiganUnited States, United States
• DM Clinical Research - Detroit
  Southfield, MichiganUnited States, United States
• North Alabama Research Center
  Athens, AlabamaUnited States, United States
• The Vanderbilt Vaccine Research Program Clinic at The Village at Vanderbilt
  Nashville, TennesseeUnited States, United States
• Vanderbilt Investigational Drug Service (IDS)
  Nashville, TennesseeUnited States, United States
• Vanderbilt University Medical Center
  Nashville, TennesseeUnited States, United States
• Vanderbilt Vaccine Research Program Laboratory
  Nashville, TennesseeUnited States, United States
• Vanderbilt Vaccine Research Program
  Nashville, TennesseeUnited States, United States
• Ochsner Clinic Foundation - Kenner Clinical Trials Unit
  Kenner, LouisianaUnited States, United States
• Ochsner Medical Complex - The Grove
  Baton Rouge, LouisianaUnited States, United States
• Clinical Neuroscience Solutions Inc.
  Memphis, TennesseeUnited States, United States
• Ochsner Lafayette General Medical Center
  Lafayette, LouisianaUnited States, United States
• DM Clinical Research - Chicago
  Melrose Park, IllinoisUnited States, United States
• Sundance Clinical Research
  St Louis, MissouriUnited States, United States
• Washington University School of Medicine
  St Louis, MissouriUnited States, United States
• Applied Research Center of Arkansas
  Little Rock, ArkansasUnited States, United States
• DM Clinical Research- Cyfair
  Houston, TexasUnited States, United States
• Mercury Clinical Research - Santa Clara Family Clinic
  Houston, TexasUnited States, United States
• Memorial Hermann Hospital - TMC
  Houston, TexasUnited States, United States
• The University of Texas Health Science Center at Houston
  Houston, TexasUnited States, United States
• UT Physicians
  Houston, TexasUnited States, United States
• Baylor College of Medicine
  Houston, TexasUnited States, United States
• Dynamed Clinical Research, LP d/b/a DM Clinical Research
  Tomball, TexasUnited States, United States
• Northwest Houston Heart Center
  Tomball, TexasUnited States, United States
• Family Health Watch - KeyPoint Clinical Research
  Dallas, TexasUnited States, United States
• KeyPoint Clinical Research
  Dallas, TexasUnited States, United States
• North Texas Infectious Diseases Consultants, P.A
  Dallas, TexasUnited States, United States
• Cedar Health Research - Euless
  Euless, TexasUnited States, United States
• Accellacare - McFarland
  Ames, IowaUnited States, United States
• McFarland Clinic, PC
  Ames, IowaUnited States, United States
• Velocity Clinical Research, Omaha
  Omaha, NebraskaUnited States, United States
• University of Nebraska Medical Center
  Omaha, NebraskaUnited States, United States
• AMR Clinical
  Newton, KansasUnited States, United States
• Velocity Clinical Research, Sioux City
  Sioux City, IowaUnited States, United States
• Velocity Clinical Research, Grand Island
  Grand Island, NebraskaUnited States, United States
• Albuquerque Clinical Trials, Inc.
  Albuquerque, New MexicoUnited States, United States
• Epic Medical Research-Sun City
  Sun City, ArizonaUnited States, United States
• J. Lewis Research, Inc. / Foothill Family Clinic South
  Salt Lake City, UtahUnited States, United States
• Kaiser Permanente - San Diego Medical Center
  San Diego, CaliforniaUnited States, United States
• Kaiser Permanente Viewridge Medical Office
  San Diego, CaliforniaUnited States, United States
• Velocity Clinical Research, San Bernardino
  San Bernardino, CaliforniaUnited States, United States
• Kaiser Permanente Ontario Medical Center
  Ontario, CaliforniaUnited States, United States
• Southern California Permanente Medical Group
  Pasadena, CaliforniaUnited States, United States
• Kaiser Permanente Los Angeles Medical Center
  Los Angeles, CaliforniaUnited States, United States
• Kaiser Permanente Oncology Pharmacy #014C
  Los Angeles, CaliforniaUnited States, United States
• Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.
  Toluca Lake, CaliforniaUnited States, United States
• Sacramento VA Medical Center
  Mather, CaliforniaUnited States, United States
• Renown Center for Advanced Medicine
  Reno, NevadaUnited States, United States
• Renown Regional Medical Center
  Reno, NevadaUnited States, United States
• University Health
  Reno, NevadaUnited States, United States
• Kaiser Permanente Roseville
  Roseville, CaliforniaUnited States, United States
• Kaiser Permanente Sacramento
  Sacramento, CaliforniaUnited States, United States
• Kaiser Permanente South Sacramento
  Sacramento, CaliforniaUnited States, United States
• Kaiser Permanente San Jose
  San Jose, CaliforniaUnited States, United States
• Kaiser Permanente Santa Clara
  Santa Clara, CaliforniaUnited States, United States
• Diablo Clinical Research, Inc.
  Walnut Creek, CaliforniaUnited States, United States
• Kaiser Permanente Walnut Creek
  Walnut Creek, CaliforniaUnited States, United States
• Carbon Health - San Mateo - Hillsdale Mall
  San Mateo, CaliforniaUnited States, United States
• Kaiser Permanente Oakland
  Oakland, CaliforniaUnited States, United States
• Kaiser Permanente Daly City
  Daly City, CaliforniaUnited States, United States
• Nanbu Tokushukai Hospital
  Shimajiri, OkinawaJapan, Japan
• Kaiser Permanente Center for Health Research
  Portland, OregonUnited States, United States
• University of Washington - Harborview Medical Center
  Seattle, WashingtonUnited States, United States
• Kaiser Permanente Washington Health Research Institute (KPWHRI)
  Seattle, WashingtonUnited States, United States
• Providence Regional Medical Center Everett
  Everett, WashingtonUnited States, United States
• National Hospital Organization Nagasaki Medical Center
  Ōmura, NagasakiJapan, Japan
• Seishinkai Inoue Hospital
  Itoshima, FukuokaJapan, Japan
• Japanese Red Cross Kumamoto Hospital
  Kumamoto, KumamotoJapan, Japan
• Aso Iizuka Hospital
  Iizuka-shiJapan, Japan
• Fukuoka Shinmizumaki Hospital
  Onga-gunJapan, Japan
• Nozaki Tokushukai Hospital
  Daitō, OsakaJapan, Japan
• Kojunkai Daido Clinic
  Nagoya, Aichi-kenJapan, Japan
• Kamiiida daiichi General Hospital
  Nagoya, Aichi-kenJapan, Japan
• Tokyo-Eki Center-building Clinic
  Chuo-kuJapan, Japan
• Koga General Hospital
  Koga, IbarakiJapan, Japan

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